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eagT6 eagT6 tse6 tse6 vgrG1 vgrG1 tsi6 tsi6 tse5 tse5 tse7 tse7 vgrG1b vgrG1b PA3904 PA3904 tse1 tse1 vgrG1c vgrG1c tsi2 tsi2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
eagT6Hypothetical protein; Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a. (144 aa)    
Predicted Functional Partners:
tse6
Hypothetical protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.
  
 
 0.999
vgrG1
VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity.
  
  
 0.978
tsi6
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse5.
  
  
 0.971
tse5
Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein.
  
 
 0.922
tse7
Hypothetical protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7.
  
  
 0.845
vgrG1b
Conserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse7 toxin to target cells where it exerts toxicity through its nuclease domain.
  
  
 0.812
PA3904
Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).
  
 
 0.789
tse1
Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin.
  
  
 0.743
vgrG1c
Conserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity. Belongs to the VgrG protein family.
  
  
 0.736
tsi2
Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2.
   
  
 0.719
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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